Finding New Purposes for Established or Abandoned Therapeutics
It's a wonder new medications are ever developed at all. Taking a new drug from promising molecule to marketable product can cost upwards of a billion dollars and take a decade or more to move from clinical trials to approval. Oh, and the overall failure rate hovers near 95%.
Not surprisingly, the drug industry has become interested in repurposing drugs, which involves testing a medication for a therapeutic use different from its original intended use. These can be drugs already on the market, or those that didn’t pan out for their original intended use.
Well-known repositioned drug success stories include:
- Rogaine, the hair regrowth treatment, which was developed from the oral blood pressure medication minoxidil after researchers noticed that hair growth was a common side effect.
- Thalidomide, which was taken off the market in 1961 after being discovered to cause severe birth defects, but approved again by the FDA in 1998 for use in leprosy and again in 2006 for multiple myeloma
- Viagra, which was developed to treat pulmonary arterial hypertension before gaining approval in 1998 to treat erectile dysfunction.
Emory's OTT already has several repurposed drug candidates in development to treat various conditions.
BH3 mimetics were first marketed as inhibitors of pro-survival BCL-2 proteins, ultimately triggering apoptosis in cancerous cells. BH3 mimetics were repurposed by researchers Malathy Shanmugam, PhD, Richa Bajpai, PhD, and Lawrence H. Boise, PhD, from the Department of Hematology in Emory School of Medicine, as a particularly effective therapy for multiple myeloma when paired with glucose inhibitors. Inhibiting glucose metabolism in cancerous cells sensitizes them to the effects of BH3 mimetics. Researchers observed increased cell death when the two therapeutics were paired, suggesting that BH3 mimetics administered in conjunction with glucose inhibitors can prove to be a potent treatment against multiple myeloma. (Techid: 15033; view our technology brief)
DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer: Melanoma is the deadliest form of skin cancer in the US. Surgical strategies followed by chemotherapy and immunology often have a high successful rate; however, patients with a gene mutation sensitive to the patient’s diet, such as BRAF V600E mutant, may need an alternative form of treatment. Emory inventors have discovered that dehydroacetic acid (DHAA), used in cosmetics and food preservation, can help reduce the tumor size in an animal model and show no visible toxicity. Hence, DHAA could potentially be used in cancer therapeutics as an alternative treatment of BRAF V600E positive forms of cancer. (Techid: 16067; view our technology brief)
Epsilon aminocaproic acid, or EACA, was initially developed by Hanna J. Khoury, MD, who was a professor at the Emory School of Medicine, and Ana G. Antun, MD, a staff physician at the Emory School of Medicine in the Department of Hematology, as an antifibrinolytic agent to treat hemorrhage in patients with congenital bleeding disorders. EACA was also found to be a cheaper and more easily administered alternative to platelet replacement therapy. As a common, orally bioavailable FDA-approved drug, EACA is a safe and highly effective treatment alternative for patients with severe and chronic thrombocytopenia. Thrombocytopenia is a condition characterized by low platelet counts as a result of chemotherapy, which tends to kill off blood-forming cells in bone marrow. Excessive bleeding is a common problem in those with leukemia and bone marrow failure, and administration of EACA has been found to be clinically superior to standard platelet transfusions as treatment. (Techid: 13023; view our technology brief)
L-DOPA is an FDA-approved drug first developed as a treatment for Parkinson’s disease, which is characterized by low levels of dopamine in certain parts of the brain. Parkinson’s disease can be attenuated by administering the dopamine analog that is able to cross the blood brain barrier. Emory School of Medicine researchers Machelle T. Pardue, PhD and P. Michael Iuvone, PhD have discovered that L-DOPA is an effective treatment for diabetic retinopathy, which is a condition characterized by the progression of diabetes weakening retinal blood vessels, which can ultimately burst and cause cloudy vision and eventual vision loss. Research has shown that retinal neuronal dysfunction inevitably occurs before any vascular lesions are discovered in a patient. Dopamine in the brain modulates much of the visual function, and reduced levels of dopamine were found in the brains of diabetic mice models. These mice regained some retinal and visual function when treated with L-DOPA, suggesting that L-DOPA may prove to be an effective therapeutic for diabetic retinopathy. (Techid: 14057; view our technology brief)
Small molecule kinase inhibitors, such as epidermal growth factor (EGFR) inhibitors, were developed and approved for human use to slow or stop cell growth entirely for use in cancer treatment. Recently, Emory School of Medicine researchers Brian P. Pollack, MD, PhD, Richard W. Compans, PhD, and Ionna Skountzou, MD, PhD found that GFR inhibitors improved the efficacy of certain vaccines, thus making them compelling vaccine adjuvants. Adjuvants are used in combination with vaccines in the event that a vaccine cannot provide a strong enough immunological response and the required dosage or number of administrations of a particular vaccine must be limited. Topical application of these EGFR inhibitors leads to the production of cytokines and chemokines and recruitment of immune cells, enhancing the immune response to administered vaccines. (Techid: 13126; view our technology brief)
Small Molecules that Promote Osteogenesis: Bone grafting, or transplanting of bone tissues, is a growing market with a value of 2.6 billion dollars per year worldwide. Current treatments requiring a high concentration of bone morphogenetic proteins (BMP) can result in high costs, adverse side effects and set a high bar for routine clinical use. Emory researchers have found several repurposed small molecules as substitutes for BMP. The molecules have shown activity in a cell-based assay, enhancing suboptimal doses of BMP. These repurposed small molecules have been FDA approved for other indications, have lower cost, and may be administered locally, reducing adverse side effects. (Techids: 11221 & 12148; view our technology brief)
Imatinib is a protein tyrosine kinase inhibitor that was initially marketed as an anti-cancer therapeutic and has now been repurposed by Emory School of Medicine researcher Daniel Kalman, PhD as an effective treatment for multidrug-resistant varieties of Tuberculosis, or MDR-TB. MDR-TB is a variant of Tuberculosis that poses an increased threat to exposed populations, as the majority of first line of defense drugs prove to be ineffective as potential treatment options. MDR-TB uses intracellular protein kinases to enter and survive within macrophages in the body, ultimately escaping the body’s innate immune system. Imatinib has been proven to reduce bacterial loads in macrophages, particularly when used to combat rifampin-resistant strains of Tuberculosis. (Techid: 16002; view our technology brief)
PLK1 Inhibitors for the Diagnosis and Treatment of Small Cell Lung Carcinoma (SCLC): Emory inventor, Taofeek Owonikoko, has found that patients with a specific TP53 gene mutation have favorable response to PLK1 inhibitors in the treatment of Small Cell Lung Carcinoma (SCLC). SCLC is an aggressive form of lung cancer that happens often in smokers and has a high rate of recurrence in a short time period. Despite the good response to chemotherapy drugs at the initial stage, SCLC patients lack effective therapeutics due to resistance when relapse occurs. Unlike other chemotherapy treatments, PLK1 inhibitors overcome the drug-resistance of recurrent SCLC in patients with the TP53 gene mutation, which may also be used as a predictive biomarker to identify patients with sensitivity to PLK1 inhibitors. (Techid: 15128; view our technology brief)
A combination of rapamycin and the drug imatinib (Gleevec), used in the treatment of chronic myeloid leukemia, was found by researcher Jack Arbiser, MD, PhD, in dermatology, to be highly effective in decreasing tumors in mouse models of tuberous sclerosis (TS), a genetic disorder that causes non-malignant tumors to form in many different organs, primarily the brain, eyes, heart, kidney, skin, and lungs. The combination was found to be far better in preventing tumor growth than either drug alone. (Techid: 11050; view our technology brief)